Heterogeneous catalytic asymmetric dihydroxylation of olefins: A new polymeric support and a process improvement

Article abstract of DOI:10.1016/S0040-4020(01)89433-3

A new polymeric support containing a derivative of quinine 4-chlorobenzoate and alcoholic pendent groups was found to give good enantioselectivity in many cases comparable to those obtained with the free alkaloid in homogeneous reaction conditions, providing also the known advantages of the heterogeneous process. Both aromatic and aliphatic olefins were screened, using either N-methylmorpholine-N-oxide (NMO) or potassium ferricyanide (K₃Fe(CN)₆) as secondary oxidants.