Synthesis of 5-(4′-aroyl)-aryloxy methyl-4H-(1,2,4)-triazolin-3-thiol and their biological activity

Article abstract of DOI:10.1515/HC.2004.10.1.85

5-(4′-aroyl)-aryloxy methyl-4H-1,2, 4)-triazolin-3-thiols were synthesized by using substituted phenyl benzoates as the starting material. Phenyl benzoates on Fries rearrangement gave p-hydroxy benzophenones which on treatment with ethyl bromoacetate in presence of anhydrous potassium carbonate and dry acetone gave corresponding benzoyl phenyloxy esters in excellent yield. Esters were refluxed with thiosemicarbazide in presence of acetic anhydride gave cyclized title compounds. Supports for the structures of the synthesized compounds have been provided by their elemental analysis and spectral data. The newly synthesized compounds were screened for antibacterial and antifungal activities.

Full text of DOI:10.1515/HC.2004.10.1.85

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Brought to you by | University of Arizona
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Brought to you by | University of Arizona
Authenticated
Download Date | 5/25/15 4:09 PM

Brought to you by | University of Arizona
Authenticated
Download Date | 5/25/15 4:09 PM