First total synthesis of (+)-chrysanthemol

Article abstract of DOI:10.1246/cl.1997.1289

The first total synthesis of (+)-chrysanthemol (1) has been described starting from (+)-dihydrocarvone (4). The features of our synthesis are the high yield introduction of C₃-C₄ double bond into eudesmane skeleton and rearrangement of epoxide to allylic alcohol promoted by BF₃?OEt₂-Bu₄NI reagent. In our synthesis, (+)-α-eudesmol (5) has been used as a key intermediate.