113773-90-3Relevant articles and documents
An efficient synthetic strategy for introduction of C3-C4 double bond into eudesmane skeleton: First total synthesis of (+)-chrysanthemol
Chen, Yonggang,Zhou, Gang,Xiong, Zhaoming,Liu, Lijun,Li, Yulin
, p. 261 - 264 (2001)
The first enantioselective synthesis of (+)-chrysanthemol 1 was carried out starting from (+)-dihydrocarvone in ten steps. In our studies, a facile synthetic strategy has been developed for introduction of C3-C4 double bond into a eudesmane skeleton.
First total synthesis of (+)-chrysanthemol
Chen, Yonggang,Xiong, Zhaoming,Zhou, Gang,Yang, Jiong,Li, Yulin
, p. 1289 - 1290 (1997)
The first total synthesis of (+)-chrysanthemol (1) has been described starting from (+)-dihydrocarvone (4). The features of our synthesis are the high yield introduction of C3-C4 double bond into eudesmane skeleton and rearrangement of epoxide to allylic alcohol promoted by BF3?OEt2-Bu4NI reagent. In our synthesis, (+)-α-eudesmol (5) has been used as a key intermediate.
