Organic Letters
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paves a path for facile synthesis of chiral CF3-containing
internal alkenyl organonitriles. Further investigation on novel
radial-involved asymmetric remote bifunctionalization of
alkenes is still under way in our laboratory.
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ASSOCIATED CONTENT
* Supporting Information
The Supporting Information is available free of charge on the
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S
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Experimental procedure and characterization of all new
Accession Codes
CCDC 1886397 contains the supplementary crystallographic
data for this paper. These data can be obtained free of charge
bridge Crystallographic Data Centre, 12 Union Road,
Cambridge CB2 1EZ, UK; fax: +44 1223 336033.
AUTHOR INFORMATION
́
Szabo, K. J. J. Org. Chem. 2013, 78, 11087. (f) He, Y.-T.; Li, L.-H.;
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Yang, Y.-F.; Wang, Y.-Q.; Luo, J.-Y.; Liu, X.-Y.; Liang, Y.-L. Chem.
Commun. 2013, 49, 5687. (g) Lu, D.-F.; Zhu, C.-L.; Xu, H. Chem. Sci.
2013, 4, 2478. (h) Yu, Q.; Ma, S. Chem. - Eur. J. 2013, 19, 13304.
(i) Carboni, A.; Dagousset, G.; Magnier, E.; Masson, G. Org. Lett.
2014, 16, 1240. (j) Huang, L.; Zheng, S.-C.; Tan, B.; Liu, X.-Y. Org.
Lett. 2015, 17, 1589.
Corresponding Author
ORCID
Notes
(10) For selected examples of aminotrifluoromethylation, see:
(a) Egami, H.; Kawamura, S.; Miyazaki, A.; Sodeoka, M. Angew.
Chem., Int. Ed. 2013, 52, 7841. (b) Lin, J.-S.; Xiong, Y.-P.; Ma, C.-L.;
Zhao, L.-J.; Tan, B.; Liu, X.-Y. Chem. - Eur. J. 2014, 20, 1332.
(c) Xiong, Y.-P.; Wu, M.-Y.; Zhang, X.-Y.; Ma, C.-L.; Huang, L.;
Zhao, L.-J.; Tan, B.; Liu, X.-Y. Org. Lett. 2014, 16, 1000.
(d) Kawamura, S.; Egami, H.; Sodeoka, M. J. Am. Chem. Soc. 2015,
137, 4865. (e) Shen, K.; Wang, Q. Org. Chem. Front. 2016, 3, 222.
(f) Yu, L.-Z.; Wei, Y.; Shi, M. Chem. Commun. 2016, 52, 13163.
(11) For selected examples of cascade reactions via trifluoromethy-
lation/cyclization, see: (a) Zhang, L.; Li, Z.; Liu, Z.-Q. Org. Lett.
2014, 16, 3688. (b) He, Y.-T.; Li, L.-H.; Zhou, Z.-Z.; Hua, H.-L.; Qiu,
Y.-F.; Liu, X.-Y.; Liang, Y.-M. Org. Lett. 2014, 16, 3896. (c) Zheng, J.;
Deng, Z.; Zhang, Y.; Cui, S. Adv. Synth. Catal. 2016, 358, 746.
(12) (a) Wang, F.; Wang, D.; Wan, X.; Wu, L.; Chen, P.; Liu, G. J.
Am. Chem. Soc. 2016, 138, 15547. (b) Wu, L.; Wang, F.; Wan, X.;
Wang, D.; Chen, P.; Liu, G. J. Am. Chem. Soc. 2017, 139, 2904. (c) Fu,
L.; Zhou, S.; Wan, X.; Chen, P.; Liu, G. J. Am. Chem. Soc. 2018, 140,
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X.-Y. J. Am. Chem. Soc. 2016, 138, 9357. (f) Cheng, Y.-F.; Dong, X.-
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Chen, S.; Liu, X.-Y. Nat. Commun. 2017, 8, 14841. (h) Li, X.-T.; Gu,
Q.-S.; Dong, X.-Y.; Meng, X.; Liu, X.-Y. Angew. Chem., Int. Ed. 2018,
57, 7668.
The authors declare no competing financial interest.
ACKNOWLEDGMENTS
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We gratefully acknowledge the National Basic Research
Program of China (973 Program 2015CB856600) and the
National Science Foundation of China (21971228, 21772187,
21522208) for financial support.
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