Palladium-catalyzed aldol-type condensation by enol esters with SnCl2

Article abstract of DOI:10.1016/S0040-4039(00)61644-1

Using PdCl₂(PhCN)₂-SnCl₂, enol esters caused aldol-type condensation with aldehydes at 50°C in acetonitrile to produce (E)-α,β-unsaturated carbonyl compounds. Cyclic enol ester such as α-angelicalactone also reacted with aldehydes under the same conditions to afford γ-substituted β-acetyle-γ-butyrolactones and/or 5-substituted 4-acetyl-2(5H)-furanones.