The study of phosphoramidite as O-phosphitylation agent and its reactivity

Article abstract of DOI:10.1080/10426500008045253

O-phosphorylated peptide and amino acid are important in living system. In this paper, Dialkyl-N,N-dialkyl phosphoramidites (DDPA) 3 were synthesized using two methods. The reaction of DDPA with the hydroxyl group of the corresponding amino acids in the presence of tetrazole, followed by oxidation, gave O-phosphoryl amino acid methyl esters in a good yield. A systematical study of the reactivity of DDPA was presented too.

Full text of DOI:10.1080/10426500008045253

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Phosphorus, Sulfur, and Silicon
and the Related Elements
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THE STUDY OF
PHOSPHORAMIDITE AS O-
PHOSPHITYLATION AGENT AND
ITS REACTIVITY
a
a
a
Shui-Bing Chen , Yan-Mei Li , Shi-Zhong Luo
,
a
a
a
Gang Zhao , Bo Tan & Yu-Fen Zhao
a
Bioorganic Phosphorus Laboratory, Department of
Chemistry, Tsinghua University, Beijing, 100084, P.R.
China
Published online: 27 Oct 2006.
To cite this article: Shui-Bing Chen , Yan-Mei Li , Shi-Zhong Luo , Gang Zhao , Bo
Tan & Yu-Fen Zhao (2000) THE STUDY OF PHOSPHORAMIDITE AS O-PHOSPHITYLATION
AGENT AND ITS REACTIVITY, Phosphorus, Sulfur, and Silicon and the Related Elements,
164:1, 277-291, DOI: 10.1080/10426500008045253
To link to this article: http://dx.doi.org/10.1080/10426500008045253
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