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ChemComm
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DOI: 10.1039/C8CC03253J
COMMUNICATION
Journal Name
whereas a large one would deliver lower but contrasted as to be relevant to yield contrasted spatial organizations at
concentrations of and . Hence we exemplified the the 100 µm range. Since the rate constants of the self-
D
C
relevance of a self-immolative chemically-encoded timer immolative motif could be tuned by predictable alterations of
sequentially releasing two chemicals to generate steady-state its structure, various kinetically-governed molecular
layered molecular organizations in a liquid. Using a model organizations could be obtained as shown by numerical
liberating fluorophores, we demonstrated that the simulations so as to find a great variety of applications ranging
investigated timer could release the first substrate twenty from chemical biology to material science.
times faster than the second one at the 10-500 s timescale so
a
b
c
d
e
f
Fig. 3 Tunability of cS
C
2
(DE/C)-like timers for dual delivery of molecules at tailored range and concentrations. Dependence of the normalized maximal value Dmax/c
and h of the concentration profiles in and resulting from activation of cS (DE/C)-like timers by varying k
in the [10 -10 ]s range, c-f) k = 1 s and k in the [10 -10 ]s range. Parameter values: = 0.1 mm,
0
and
max/c
0
and of the relative width at half height h
D
/
R
C
/
R
C
D
2
1
-
-
1
= 1 s and k
-7
2
-1
-1
-7
2
-1
-9
2 -1
3
k . a,b) k
3
1
, k
2
1
, k
2 3
R
d
D = 10 m .s ; k = 0.1 s
This work was supported by the ANR Kituse, INSERM
Photocancer project) and LabEx LERMIT. S.S. is a “Ligue
9
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