A novel oxidative decarboxylation of α-substituted α-hydroxy acids by a functionalized oxidation-active flavin mimic in the presence of a metal ion in t-butyl alcohol

Article abstract of DOI:10.1246/cl.1996.381

A benzo-dipteridine bearing a bipyridin-6-ylmethyl moiety (6-bpy-BDP_ox) was found to conduct oxidative decarboxylation of a-methyl mandelic and benzylic acids to give acetophenone and benzophenone and the reduced form (6-bpy-BDP_red) in the presence of Ni²⁺ and DBU in t-BuOH.