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130209-82-4

Basic Information
CAS No.: 130209-82-4
Name: Latanoprost
Molecular Structure:
Molecular Structure of 130209-82-4 (Latanoprost)
Formula: C26H40O5
Molecular Weight: 432.66
Synonyms: Lata prostaglandin;Latanoprost [USAN:BAN:INN];XA 41;Xalatan (TN);5-Heptenoic acid, 7-(3,5-dihydroxy-2-(3-hydroxy-5-phenylpentyl)cyclopentyl)-, 1-methylethyl ester, (1R-(1-alpha(Z),2-beta(R*),3-alpha,5-alpha))-;Xalatan;PhXA 41;Isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((3R)-3-hydroxy-5-phenylpentyl)cyclopentyl)-5-heptenoate;Latanoprost (JAN/USAN);
EINECS: 634-172-9
Density: 1.093 g/cm3
Melting Point:
Boiling Point: 583.8 °C at 760 mmHg
Flash Point: 188.3 °C
Solubility: Soluble in: DMSO (25 mg/mL); ethanol (25 mg/mL)
Appearance: pale yellow oil
Hazard Symbols:
Risk Codes:
Safety:
Transport Information:
PSA: 86.99000
LogP: 4.18640
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41639-83-2
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Chemistry

Formula: C26H40O5 
Mol. mass :432.593 g/mol
Other name:Latanoprost
XALATAN the brand name of Xalatan manufactured by Pfizer.It is freely soluble in DMSO.
Following is the molecular structure of XALATAN:

Uses

   XALATAN ophthalmic solution is a topical medication used for controlling the progression of glaucoma or ocular hypertension by reducing intraocular pressure.
  XALATAN is also a prostaglandin analogue that works by increasing the outflow of aqueous fluid from the eyes.

Toxicity Data With Reference

1.   

ocu-man TDLo:33 µL/kg/25D-I:EYE

   AJOPAA    American Journal of Ophthalmology. 124 (1997),683.
2.   

ocu-man TDLo:99 µL/kg/20W-I:SKN

   AJOPAA    American Journal of Ophthalmology. 124 (1997),544.
3.   

ocu-wmn TDLo:4 nL/kg/5W-I:EYE

   AJOPAA    American Journal of Ophthalmology. 127 (1999),91.
4.   

orl-rat LD50:>50 µg/kg

   YAKUD5    Gekkan Yakuji. Pharmaceuticals Monthly. 42 (2000),195.
5.   

ivn-rat LD50:>2 mg/kg

   YAKUD5    Gekkan Yakuji. Pharmaceuticals Monthly. 42 (2000),195.
6.   

orl-mus LD50:>50 µg/kg

   YAKUD5    Gekkan Yakuji. Pharmaceuticals Monthly. 42 (2000),195.
7.   

ivn-mus LD50:>2 mg/kg

   YAKUD5    Gekkan Yakuji. Pharmaceuticals Monthly. 42 (2000),195.
8.   

ivn-dog LD50:>680 µg/kg

   YAKUD5    Gekkan Yakuji. Pharmaceuticals Monthly. 42 (2000),195.

RTECS : MJ9669550

Safety Profile

A poison by ingestion and intravenous route. Human systemic effects. When heated to decomposition it emits acrid smoke and irritating vapors.