Palladium and nickel catalyzed hydroxycarbonylation of a steroidal bromodiene in the synthesis of episteride, a potent 5α-reductase inhibitor

Article abstract of DOI:10.1080/00397919808006865

Androst-4-en-3-one-17β-carboxylic acid 1 was converted to 3-bromo-N- (l,1-dimethylethyl) androsta-3,5-diene-17-β-carboxamide 2 by reaction with DMF/oxalyl bromide and quenching into t-butylamine. 2 was converted to 3 (R=H) by nickel cyanide catalyzed hydr

Full text of DOI:10.1080/00397919808006865

Synthetic Communications
ISSN: 0039-7911 (Print) 1532-2432 (Online) Journal homepage: http://www.tandfonline.com/loi/lsyc20
Palladium and Nickel Catalyzed
Hydroxycarbonylation of a Steroidal Bromodiene
in the Synthesis of Episteride, a Potent 5α-
Reductase Inhibitor
Michael A. McGuire∗ , Edmund Sorenson , Donald N. Klein & Neil H. Baine
To cite this article: Michael A. McGuire∗ , Edmund Sorenson , Donald N. Klein & Neil H. Baine
(
1998) Palladium and Nickel Catalyzed Hydroxycarbonylation of a Steroidal Bromodiene in
the Synthesis of Episteride, a Potent 5α-Reductase Inhibitor, Synthetic Communications, 28:9,
611-1615, DOI: 10.1080/00397919808006865
1
To link to this article: http://dx.doi.org/10.1080/00397919808006865
Published online: 22 Aug 2006.
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Date: 28 January 2016, At: 12:25