3,4-Dimethyl-4-(3-hydroxyphenyl)piperidines: Opioid Antagonists with Potent Anorectant Activity

DOI: 10.1021/jm00072a002

Source and publish data:

Journal of Medicinal Chemistry p. 2842 - 2850 (1993)

Update date:2022-08-29

Topics:

Authors:

Mitch, Charles H.

Leander, J. David

Mendelsohn, Laurane G.

Shaw, Walter N.

Wong, David T.

et al. et al.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00072a002

A series of (3R^*,4R^*)-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine opioid antagonists with varying substituents on the nitrogen were evaluated for either effect on food consumption in obese Zucker rats.Opioid affinity (μ, κ, and δ for

Full text of DOI:10.1021/jm00072a002

Products guided by the article

Product name:3-[1-[(S)-3-Hydroxy-3-cyclohexylpropyl]-3α,4-dimethylpiperidine-4α-yl]phenol

Cas No:119193-09-8

R&D Labs maybe for 119193-09-8

Anhui New Star Pharmaceutical Development Co., Ltd

Contact:013956922763

Address:Floor 3, F9A, F Workshop, No.110 Kexue Road, High-Tech Development Zone, Hefei, Anhui ,China
ShenZhen InnoSyn Biotech Co.,Ltd

website:http://www.innosyns.com

Contact:+86-755-28351685

Address:Floor 5 & 6, Building A1, HAIKEXING Strategic Innovative Industrial Park, 16 BaoShan Road, PingShan District
XinChem Corporation

Contact:+86 21 34123252

Address:14, 4580 Dushi, Shanghai, China
Tractus Company Limited

Contact:+852-8198 2399

Address:9E, Leapont Industrial Building, 18-28 Wo Liu Hang Road, Shatin, New Territories, Hong Kong
HANGZHOU TOYOND BIOTECH CO., LTD

Contact:+86-571-86965177

Address:No. 189, Fengqi East Road, Hangzhou, China

Relevant to this article

Synthesis, structural characterization and antimycobacterial evaluation of several halogenated non-nitro benzothiazinones

Doi:10.1007/s00044-021-02735-4
(2021)
Design, synthesis and biological evaluation of novel sesquiterpene mustards as potential anticancer agents

Doi:10.1016/j.ejmech.2015.03.001
(2015)
Mild and efficient procedure for acetylation and formylation of alcohols in the presence of Mg(HSO₄)₂

Doi:10.1007/s11178-005-0217-8
(2005)
Indole- and indoline-based kainate analogues with antagonist activity at ionotropic glutamate receptors

Doi:10.1016/j.bmcl.2005.05.098
(2005)
A practical method for enantioselective synthesis of all-carbon quaternary stereogenic centers through NHC-Cu-catalyzed conjugate additions of alkyl- and arylzinc reagents to β-substituted cyclic enones

Doi:10.1021/ja062061o
(2006)
Synthesis of novel glycoconjugates derived from alkynyl heterocycles through a click approach

Doi:10.1080/00397911.2011.637655
(2013)

Article Doi