Chemical and Pharmaceutical Bulletin p. 698 - 701 (1994)
Update date:2022-08-16
Topics:
Fatimi
Lagorce
Duroux
Chabernaud
Buxeraud
Raby
In an investigation of the anti-inflammatory properties of five-membered ring nitrogen-containing heterocyclic compounds, two series of derivatives of imidazole were prepared by altering the sites of substitution and by joining aliphatic chains to the nitrogen atom in the 1 position of the imidazole ring. Some of them were more potent inhibitors of carragenan-induced edema than indomethacin. An electron spin resonance study indicated that these compounds possess anti-radical activity.
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