Bioorganic and Medicinal Chemistry Letters p. 3653 - 3656 (1998)
Update date:2022-08-16
Topics:
Pfizenmayer, Amy J.
Vera, Matthew D.
Ding, Xiaobin
Xiao, Dong
Chen, Wei-Chuan
Joullie, Madeleine M.
Tandon, Deepika
Toogood, Peter L.
A didemnin B analog containing a Tic (1,2,3,4-tetrahydroisoquinoline-3- carboxylic acid) as a comformationally restrained replacement for tyrosine has been synthesized and shown to have comparable potency as a protein biosynthesis inhibitor. Synthetic hig
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