Direct NMR assay of the enantiomeric purity of chiral β-hydroxy esters by using quinine as chiral solvating agent

Article abstract of DOI:10.1016/0957-4166(95)00256-O

The use of quinine as a chiral solvating agent for NMR spectroscopy affords a general method for the enantiomeric purity determination of β-hydroxyesters. The ester group represents the most suitable probe for the measurements, which can be optimized by varying the molar ratio ester/quinine, the total concentration or the temperature.