A highly efficient synthesis of the antiviral agent (+)-cyclaradine involving the regioselective cleavage of epoxide by neighboring participation

Article abstract of DOI:10.1016/S0040-4039(97)00234-7

(+)-Cyclaradine, carbocyclic arabinofuranosyladenine having anti-HSV activity, has been synthesized from (-)-2-azabicyclo[2.2.1]hept-5-en-3-one in only seven steps. The method involves the novel ring cleavage of epoxide by neighboring participation.