Enantioselective Hetero-Diels-Alder reaction with glyoxylate catalyzed by chiral titanium complex: Asymmetric synthesis of the lactone portion of mevinolin and compactin

Article abstract of DOI:10.1016/S0040-4039(00)92124-5

Asymmetric Diels-Alder reaction with methyl glyoxylate catalyzed by the chiral titanium complex 1 provides the dihydropyran carboxylate in high enantiomeric purity, which can be converted to the lactone portion of mevinolin or compactin.