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70-18-8

Basic Information
CAS No.: 70-18-8
Name: Glutathione
Molecular Structure:
Molecular Structure of 70-18-8 (Glutathione)
Formula: C10H17N3O6S
Molecular Weight: 307.36
Synonyms: Glutathione(8CI);Glycine, N-(N-L-g-glutamyl-L-cysteinyl)-;Copren;Glutathion;Glutathione-SH;Glutide;Glutinal;Isethion;L-Glutathione;N-(N-L-g-Glutamyl-L-cysteinyl)glycine;Tathione;g-Glutamylcysteinylglycine;g-L-Glutamyl-L-cysteinylglycine;Glycine, L-g-glutamyl-L-cysteinyl-;GSH;L-Glutathione Reduced;
EINECS: 200-725-4
Density: 1.441 g/cm3
Melting Point: 192-195 °C (dec.)(lit.)
Boiling Point: 754.492 °C at 760 mmHg
Flash Point: 410.102 °C
Solubility: Soluble in water
Appearance: White cryst. powder
Hazard Symbols: IrritantXi
Risk Codes: 68-36/37/38
Safety: 24/25-36/37/39-27-26
Transport Information:
PSA: 197.62000
LogP: -0.72400
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  • China biggest manufacturer,Glutathione,70-18-8

  • Casno:

    70-18-8

    China biggest manufacturer,Glutathione,70-18-8

    Min.Order: 1 Gram

    FOB Price:  USD $ 5.0-5.0/Gram

    Advantages of GIHI Peptide 1. Purity HPLC: ≥98%, Peptide content: ≥80% 2. Acetic acid: ≤15%; moisture: ≤5% 3. Short delivery period GIHI CHEMICALS exported this product to many countries and regions at best price. if you are looking

    GIHI CHEMICALS CO.,LIMITED, its former company is a small manufacturer who is specialized in the production of ester products which are used in the daily chemicals ,cosmetic produc

  •  GIHI CHEMICALS CO.,LIMITED

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:571-86217390

    Address:Huacai International Building,Sandun,Westlake District,Hangzhou 310030,Zhejiang,China

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Consensus Reports

EPA Genetic Toxicology Program. Reported in EPA TSCA Inventory.

Specification

Glutathione (CAS NO.70-18-8), its Synonyms are Glycine, N-(N-L-gamma-Glutamyl-L-cysteinyl)glycine ; Copren ; Deltathione ; Glutide ; Glutinal ; Glutathione ; gamma-L-Glutamylcysteinylglycine ; Glycine, L-gamma-glutamyl-L-cysteinyl- . It is white powder. Glutathione (GSH) is a tripeptide with a gamma peptide linkage between the amine group of cysteine (which is attached by normal peptide linkage to a glycine) and the carboxyl group of the glutamate side-chain. It is an antioxidant, preventing damage to important cellular components caused by reactive oxygen species such as free radicals and peroxides.

Physical properties about Glutathione are: (1)ACD/LogP: -1.645; (2)# of Rule of 5 Violations: 1; (3)ACD/LogD (pH 5.5): -5.12; (4)ACD/LogD (pH 7.4): -5.15; (5)ACD/BCF (pH 5.5): 1.00; (6)ACD/BCF (pH 7.4): 1.00; (7)ACD/KOC (pH 5.5): 1.00 ; (8)ACD/KOC (pH 7.4): 1.00; (9)#H bond acceptors: 9; (10)#H bond donors: 6; (11)#Freely Rotating Bonds: 11; (12)Index of Refraction: 1.572; (13)Molar Refractivity: 70.105 cm3; (14)Molar Volume: 213.204 cm3; (15)Polarizability: 27.792 10-24cm3; (16)Surface Tension: 69.3659973144531 dyne/cm; (17)Density: 1.441 g/cm3; (18)Flash Point: 410.102 °C; (19)Enthalpy of Vaporization: 119.618 kJ/mol; (20)Boiling Point: 754.492 °C at 760 mmHg

Uses of Glutathione: Glutathione (CAS NO.70-18-8) is a biological and chemical reagents, detoxification drugs which is mainly used for poisoning such as heavy metals, acrylonitrile, fluoride, carbon monoxide and organic solvents. Glutathione can also decrease the concentrations of inflammatory cytokines (IL-6, IL-18), neutrophils in lung tissue and increase the level of serum Ca2+ and be useful for the treatment of ANP.

When you are using this chemical, please be cautious about it as the following:
1.Avoid contact with skin and eyes;
2.Wear suitable protective clothing, gloves and eye/face protection;
3.Take off immediately all contaminated clothing;
4.In case of contact with eyes, rinse immediately with plenty of water and seek medical advice;

You can still convert the following datas into molecular structure:
(1)InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/t5-,6-/m0/s1;
(2)InChIKey=RWSXRVCMGQZWBV-WDSKDSINSA-N;
(3)SmilesN[C@@H](CCC(=O)N[C@H](C(=O)NCC(=O)O)CS)C(=O)O;

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intramuscular 4gm/kg (4000mg/kg)   "Modern Pharmaceuticals of Japan, III," Tokyo, Japan Pharmaceutical, Medical and Dental Suppl Exporters' Assoc., 1968Vol. -, Pg. 97, 1968.
mouse LD50 intraperitoneal 4020mg/kg (4020mg/kg)   "Modern Pharmaceuticals of Japan, IV," Tokyo, Japan Pharmaceutical, Medical and Dental Supply Exporters' Assoc., 1972Vol. -, Pg. 93, 1972.
mouse LD50 intravenous 2238mg/kg (2238mg/kg)   Japanese Journal of Antibiotics. Vol. 38, Pg. 137, 1985.
 
mouse LD50 oral 5gm/kg (5000mg/kg)   "Modern Pharmaceuticals of Japan, IV," Tokyo, Japan Pharmaceutical, Medical and Dental Supply Exporters' Assoc., 1972Vol. -, Pg. 93, 1972.
mouse LD50 subcutaneous 5gm/kg (5000mg/kg)   "Modern Pharmaceuticals of Japan, IV," Tokyo, Japan Pharmaceutical, Medical and Dental Supply Exporters' Assoc., 1972Vol. -, Pg. 93, 1972.
rabbit LD50 intravenous > 2gm/kg (2000mg/kg)   Biochemical Journal. Vol. 41, Pg. 325, 1947.