Divergent and scalable synthesis of α-hydroxy/keto-β-amino acid analogues by the catalytic enantioselective addition of glyoxylate cyanohydrin to imines

Article abstract of DOI:10.1021/acscatal.9b03394

The catalytic enantioselective addition of glyoxylate cyanohydrin to imines to afford α-keto-β-amino acid equivalents is reported. Sterically tuned aminobenzothiadiazine catalysts provided high yields and stereoselectivities (up to 100% yield, 99% ee, >99