Tetrahedron Letters p. 1219 - 1220 (1980)
Update date:2022-08-16
Topics:
Grunewald, Gary L.
Brouillette, Wayne J.
Finney, Jay A.
The trimethylsilyl ethers of the cyanohydrins of aryl-alkyl ketones and diaryl ketones afforded the corresponding α-hydroxyamides upon hydrolysis with HCl or HNO3/HCO2H.The method is advantageous for ketones do not readily undergo addition of HCN.
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