Role of Metalation in the Topoisomerase IIα inhibition and antiproliferation activity of a series of α-heterocyclic-N 4-substituted thiosemicarbazones and their Cu(II) complexes

DOI: 10.1021/jm101532u

Source and publish data:

Journal of Medicinal Chemistry p. 2391 - 2398 (2011)

Update date:2022-08-11

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Authors:

Zeglis, Brian M.

Divilov, Vadim

Lewis, Jason S.

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Article abstract of DOI:10.1021/jm101532u

The topoisomerase-IIα inhibition and antiproliferative activity of α-heterocyclic thiosemicarbazones and their corresponding copper(II) complexes have been investigated. The Cu^II(thiosemicarbazonato)Cl complexes were shown to catalytically inhi

Full text of DOI:10.1021/jm101532u

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