40123-20-4Relevant academic research and scientific papers
General base-catalyzed hydrolysis and carbonyl-18O exchange of N-(4- nitrobenzoyl)pyrrole
Beach, Laurence J.,Batchelor, Raymond J.,Einstein, Frederick W.B.,Bennet, Andrew J.
, p. 1410 - 1417 (1998)
Base-promoted hydrolysis kinetics for N-(4-nitrobenzoyl)pyrrole (1) have been measured as a function of buffer concentration at several pH values at 25°C. In addition carbonyl-18O exchange kinetics have been determined at a single pH value (9.4
A practical preparation of highly versatile N-acylpyrroles from 2,4,4-trimethoxybutan-1-amine
Maehara, Tomoaki,Kanno, Rentaro,Yokoshima, Satoshi,Fukuyama, Tohru
supporting information; experimental part, p. 1946 - 1948 (2012/06/01)
A novel method for the preparation of N-acylpyrrole is described. The method involves condensation of carboxylic acids with 2,4,4-trimethoxybutan-1- amine, followed by acid-mediated cyclization to form the pyrrole ring. The preparative procedure is highly
A convenient synthesis of N-acylpyrroles from primary aromatic amides
Ekkati, Anil R.,Bates, Dallas K.
, p. 1959 - 1961 (2007/10/03)
Synthesis of N-acylpyrroles in 45-85% isolated yield from primary aromatic amides and excess 2,5-dimethoxytetrahydrofuran in presence of one equivalent of thionyl chloride is reported. This method has several advantages including short reaction times, mild reaction conditions, and easy workup. The technique works particularly well for deactivated aromatic amides.
Synthesis and nuclear magnetic resonance spectroscopic studies of 1- arylpyrroles
Lee, Chang Kiu,Jun, Jung Ho,Yu, Ji Sook
, p. 15 - 24 (2007/10/03)
A series of m- and p-substituted 1-phenyl, 1-benzyl, 1-benzoyl, and 1- (2-phenylethyl)pyrroles was prepared and their 1H and 13C nmr spectroscopic characteristics were examined. In general, good correlations were observed between the chemical shift values of the β-H and the β-C of pyrroles [except 1-(2-phenylethyl)pyrroles] and the Hammettt σ. The observation may be explained in terms of the electronic effects of the substituents which are transmitted through bonds and through space by interaction of the p orbitals between β-Cs of the pyrrole ring and m- and p- Cs of the phenyl ring. Substituent constants of 1-pyrrolyl, 1-pyrrolylmethyl, and 1-pyrroloyl groups for the 1H and 13C chemical shifts of phenyl ring are also presented.
