Bulletin of the Chemical Society of Japan p. 1751 - 1754 (1992)
Update date:2022-08-17
Topics:
Oyama, Kiyotaka
Itoh, Mikio
Nonaka, Yuji
A new method was studied for optical resolution of racemic amino acids esters by using, as resolving agents, N-protected L-α-aspartyl-L-phenylalanine alkyl esters, typically, N-benzyloxycarbonyl-L-α-aspartyl-L-phenylalanine methyl ester, the precursor to the synthetic sweetener aspartame.Thus, when the dipeptide and racemic amino acid ester were mixed in solvents, precipitation took place by formation of salt preferentially with D-amino acid ester to effect the optical resolution.
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