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late (56 mg, 0.29 mmol, 97%) was dissolved in 1 ml of
dry 1,2-dimethoxyethane and added to a stirred sus-
pension of 14 mg (0.37 mmol) of LiAlH4 in 10 ml of
dry 1,2-dimethoxyethane. After stirring for 15 h at
room temperature, ®rst 0.5 ml of a saturated NH4Cl
solution and ®nally 1 ml of diluted HCl solution (1.2
mol/l) were added. The solvent was removed under
reduced pressure and the salts were extracted once
with dichloromethane. After that, the salts were dis-
solved in diluted HCl solution and extracted three
times with dichloromethane. The combined organic
layers were dried over Na2SO4 and the solvent
removed. This yielded 34 mg (0.20 mmol, 70%) of 1-
(4'-methoxyphenyl)-1,2-ethanediol. Its spectroscopic
and spectrometric data are identical to those given
above.
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1
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Amorphous yellow powder, Mp 205±2108. H-NMR
(500.13 MHz, CDCl3): d 1.01 (3H, s, H-27), 1.02 (3H,
s, H-19), 1.06 (3H, s, H-18), 1.07 (3H, s, H-25), 1.24
(3H, s, H-26), 2.44 (1H, m, H-17), 2.61 (1H, m, H-20),
3.32 (3H, s, OMe), 3.33 (3H, s, OMe), 3.43 (1H, dd,
J 8:5, 7.2 Hz, H-3), 4.59 (1H, t, J 5:2 Hz, H-24).
13C-NMR (125.76 MHz, CDCl3): see Table 3. EI-MS
m/z (rel. int): 445 [M OMe]+ (21), 444
[M OMe H]+ (61), 430 [M OMe Me]+ (34), 429
[M OMe Me H]+ (100), 411 (61), 397 (45), 379
(66), 71 (98).
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von
Untersuchungen
Ergosterolperoxid. Pharmazie 44, 579±580.
zur
antiviralen
Wirksamkeit
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Acknowledgements
Rosecke, J., Konig, W.A., 1999. Steroids from the fungus Fomitopsis
pinicola. Phytochemistry 52, 1621±1627.
The ®nancial support of the Fonds der Chemischen
Industrie is gratefully acknowledged.
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