The use of zinc enolates in the synthesis of a key intermediate for the preparation of trinem antibiotics

Article abstract of DOI:10.1016/0040-4039(96)01606-1

The stereoselective preparation of 2a, a key intermediate in the synthesis of the broad spectrum tricyclic β-lactam antibiotic GV104326 1, by the reaction of a zinc enolate derived from chiral non-racemic 2-methoxycyclohexanone with azetidinone 3 is described.