European Journal of Medicinal Chemistry p. 231 - 235 (1991)
Update date:2022-08-11
Topics:
Diafi, L.
Rubat, C.
Coudert, P.
Bastide, P.
Margoum, N.
Tronche, P.
Synthesis and influence of the stereochemistry on anticonvulsant activity of 1-aza<3.3.0>bicyclo-octanes.New diastereo-isomeric 1-aza<3.3.0>bicyclo octanes have been prepared by a photochemistry process.They have been separated by chromatography and identified by 300 MHz 1H-NMR study.Trans derivative has shown more marked anticonvulsant effects than cis isomere did.Graphic modelling revealed the importance of the aromatic ring position in relation to bicyclic system for activity.
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