Synthesis and biological evaluation of flavonoids and related compounds as gastroprotective agents

Article abstract of DOI:10.1016/0960-894X(96)00134-5

Several analogs of the gastroprotective molecule flavone have been synthesized and evaluated for gastroprotective activity. A C2-C3 double bond and an intact C ring appear necessary for optimum activity. Activity can be retained by replacing the 2-phenyl substituent with other groups but is eliminated when this ring is moved from the 2- to the 3-position.