Mechanistic study on the inactivation of general Acyl-CoA dehydrogenase by a metabolite of hypoglycin A

Article abstract of DOI:10.1021/ja00019a040

General acyl-CoA dehydrogenase (GAD) is a flavin-dependent (FAD) enzyme that catalyzes the oxidation of a fatty acyl-CoA to the corresponding α,β-enolyl-CoA. When GAD is exposed to (methylenecyclopropyl)acetyl-CoA (MCPA-CoA), a metabolite of hypoglycin A