28918-09-4

Upstream product

• 5398-64-1 2-benzylidene-1,3-diphenylpropane-1,3-dione 
• 120-46-7 1,3-diphenylpropanedione 
• 100-51-6 benzyl alcohol 
• 71115-31-6 3-imino-1,3,N-triphenylprop-1-enylamine 
• 98-88-4 benzoyl chloride 
• 94-41-7 benzalacetophenone 
• 140-11-4 Benzyl acetate 
• 100-52-7 benzaldehyde 
• 908094-04-2 phenyldiazomethane 
• 98-86-2 acetophenone 
• 93-89-0 benzoic acid ethyl ester 
• 620-05-3 iodomethylbenzene 
• 94404-55-4 ((Z)-2-Benzyl-3-imino-1,3-diphenyl-propenyl)-phenyl-amine 
• 66310-10-9 N-benzyl-2,4,6-triphenylpyridinium tetrafluoroborate 

Downstream Products

• 14688-32-5 4-benzyl-3,5-diphenylisoxazole 
• 955955-05-2 3,5-diphenyl-4-phenylmethyl-1H-pyrazole 
• 106565-22-4 (1S,3S/1R,3R)-2-benzyl-1,3-diphenyl-1,3-propanediol 
• 106471-22-1 (1R,2s,3S)-2-benzyl-1,3-diphenyl-1,3-propanediol 
• 106565-23-5 (1R,2r,3S)-2-benzyl-1,3-diphenyl-1,3-propanediol 
• 1083-30-3 dihydrochalcone 
• 65-85-0 benzoic acid 
• 137743-31-8 9-(4-Benzyl-3,5-diphenyl-pyrazol-1-yl)-nonanoic acid 
• 1198786-85-4 (Z)-2-benzyl-1,3-diphenyl-3-(2-(propylthio)ethylamino)prop-2-en-1-one 
• 1005501-69-8 3-diazo-4-phenyl-2-butanone 
• 1373153-95-7 C₃₈H₄₄N₂O₈ 
• 1375090-85-9 2-benzyl-1,3-diphenylpropane-1,3-diol 
• 1375090-82-6 2-benzyl-1,3-diphenylpropane-1,3-diol 
• 1373153-99-1 C₃₈H₄₄N₂O₈ 

Relevant academic research and scientific papers

New antineoplastic agent based on a dibenzoylmethane derivative: Cytotoxic effect and direct interaction with DNA

Melanoma accounts for only 4% of all skin cancers but is among the most lethal cutaneous neoplasms. Dacarbazine is the drug of choice for the treatment of melanoma in Brazil through the public health system mainly because of its low cost. However, it is a

Dibenzoylmethane derivative inhibits melanoma cancer in vitro and in vivo through induction of intrinsic and extrinsic apoptotic pathways

Malignant melanoma has a low incidence, but is the most lethal type of skin cancer. Studies have shown that dibenzoylmethanes (DBMs) have interesting biological activities, including antineoplastic properties. These findings led us to investigate whether

The Employment of Sodium Hydride as a Michael Donor in Palladium-catalyzed Reductions of α, β-Unsaturated Carbonyl Compounds

Sodium hydride was employed as a Michael donor under the catalysis of PdCl2 for 1,4-conjugate reductions of α, β-unsaturated carbonyl compounds, which features operational simplicity, mild conditions and high atom-economy. The merits of NaH as a reductant were demonstrated by the one-pot or cascade reactions for the syntheses of complex molecules. (Figure presented.).

Graphene oxide catalyzed ketone α-alkylation with alkenes: Enhancement of graphene oxide activity by hydrogen bonding

Direct α-alkylation of carbonyl compounds represents a fundamental bond forming transformation in organic synthesis. We report the first ketone-alkylation using olefins and alcohols as simple alkylating agents catalyzed by graphene oxide. Extensive studies of the graphene surface suggest a pathway involving dual activation of both coupling partners. Notably, we show that polar functional groups have a stabilizing effect on the GO surface, which results in a net enhancement of the catalytic activity. The method represents the first alkylation of carbonyl compounds using graphenes, which opens the door for the development of an array of protocols for ketone functionalization employing common carbonyl building blocks and readily available graphenes.

Catalyst-Dependent Chemoselective Formal Insertion of Diazo Compounds into C?C or C?H Bonds of 1,3-Dicarbonyl Compounds

A catalyst-dependent chemoselective one-carbon insertion of diazo compounds into the C?C or C?H bonds of 1,3-dicarbonyl species is reported. In the presence of silver(I) triflate, diazo insertion into the C(=O)?C bond of the 1,3-dicarbonyl substrate leads

Dimethyl malonate/LHMDS system as a new protocol for generating methyl formate anion (-COOMe) in the condensed-phase Dedicated to Professor Charles H. DePuy (1927-2013)

The treatment of dimethyl malonate with LHMDS in anhydrous THF (condensed-phase) generates, in addition to the expected corresponding lithium enolate, methyl formate anion (or methoxycarbonyl anion, -COOMe) which can react with several electrophiles to give corresponding methoxycarbonyl derivatives by nucleophilic substitution reaction.

Application of a novel 1,3-diol with a benzyl backbone as chiral ligand for asymmetric oxidation of sulfides to sulfoxides

A chiral 1,3-diol with a benzyl backbone has been used for the asymmetric oxidation of sulfides to sulfoxides. Moderate to good yields and enantioselectivity (upto 87% ee) have been observed.

Palladium-catalyzed oxidative cross-coupling reaction of arylboronic acids with diazoesters for stereoselective synthesis of (E)-α,β- diarylacrylates

A Pd-catalyzed oxidative cross-coupling reaction of arylboronic acids with α-diazoesters was achieved using molecular oxygen as the sole reoxidant, and E-α,β-diarylacrylates were obtained in good yields and >20:1 E-to-Z selectivity.

Triflic acid adsorbed on silica gel as an efficient and recyclable catalyst for the addition of β-dicarbonyl compounds to alcohols and alkenes

The silica gel supported triflic acid was readily prepared via simple absorption of TfOH onto chromatographic silica gel. This solid acid was applied as an efficient catalyst for the heterogeneous addition of various β-dicarbonyl compounds to a series of alcohols and alkenes, which afforded moderate to excellent yields under solvent-free conditions or in nitromethane. Moreover, this silica gel supported catalyst surprisingly exhibited higher reaction yields in comparison with the homogeneous catalyst and can be readily recovered and reused up to 6 times with almost maintained reactivity and yields.

Direct synthesis of 1,3-diketones by Rh-catalyzed reductive α-acylation of enones

(Chemical Equation Presented) 1,3-Diketones were synthesized from α,β-unsaturated ketones by treatment with acid chlorides and Et 2Zn in the presence of RhCl(PPh3)3. This is a very simple and extremely chemoselective reaction to give the adduct at the α-position of α,β-unsaturated ketones.