Highly efficient, one-pot synthesis of novel bis-spirooxindoles with skeletal diversity: Via sequential multi-component reaction in PEG-400 as a biodegradable solvent

Article abstract of DOI:10.1039/c7ra06017c

A green and efficient one-pot, sequential, multi-component protocol has been developed for the synthesis of some novel symmetrical bis-spirooxindole derivatives from the reaction of isatins, dihalides, malono derivatives and C-H activated carbonyl compoun