19437-45-7

Usage

Derivative of imidazole

A chemical compound with a ring structure that is similar to imidazole but with a different side chain or functional group attached to it.

Contains an amine group

A functional group with a nitrogen atom bonded to two hydrogen atoms, which gives the compound basic properties.

Building block for the synthesis of various pharmaceuticals and organic compounds

It can be used as a starting material or intermediate in the synthesis of a wide range of chemical compounds.

Potential use in the treatment of various medical conditions

It has been studied for its potential therapeutic effects in the treatment of diseases such as cancer, inflammation, and neurological disorders.

Used in the synthesis of certain dyes and polymers

It can be used as a starting material or intermediate in the synthesis of dyes and polymers with specific properties.

Wide range of potential applications in the fields of medicine, chemistry, and materials science

Due to its unique chemical structure and properties, 1H-Imidazol-2-amine, 4,5-dihydrohas a broad range of potential applications in various fields.

InChI:InChI=1/C3H7N3/c4-3-5-1-2-6-3/h1-2H2,(H3,4,5,6)

Upstream product

• 506-78-5 cyanogen iodide 
• 6780-13-8 1,2-ethanediamine monohydrate 
• 14034-59-4 ethylene diamine mono-p-toluenesulfonic acid salt 
• 127099-85-8 N-Cyanoguanidine 
• 107-15-3 ethylenediamine 
• 50-01-1 guanidine hydrochloride 
• 506-68-3 bromocyane 
• 1184-90-3 aminoiminomethanesulfonic acid 
• 1651-24-7 N-(2-fluoro-ethyl)-N'-nitro-guanidine 
• 5465-96-3 2-nitroamino-1,3-diazacyclopent-2-ene 

Downstream Products

• 41899-16-5 7-methyl-2,3-dihydro-1H-imidazo[1,2-a]pyrimidin-5-one 
• 65658-66-4 7-phenyl-2,3-dihydro-1H-imidazo[1,2-a]pyrimidin-5-one 
• 81322-18-1 6,7-Dihydro-4-(4-nitrophenyl)-2-(1-pyrrolidinyl)imidazo<1,2-a>-1,3,5-triazin 
• 65658-61-9 1,2,3,5-tetrahydroimidazo<1,2-a>pyrimidin-7-(6H)-one 
• 228572-52-9 tert-Butyl (2S)-2-Benzyloxycarbonylamino-3(4-(3-(4,5-dihydro-1H-imidazol-2-ylcarbamoyl)propyloxy)phenyl)propionate 
• 137718-29-7 4,5-dihydro-2-{[3-(4,5-dihydro-1H-imidazol-2-ylcarbamoyl)benzoyl]amino}-1H-imidazole 
• 1583529-27-4 C₁₂H₁₃N₃O₃ 
• 36145-66-1 N-(imidazolin-2-yl)benzamide 

Relevant academic research and scientific papers

Targeting quorum sensing by designing azoline derivatives to inhibit the N-hexanoyl homoserine lactone-receptor CviR: Synthesis as well as biological and theoretical evaluations

To counteract bacterial resistance, we investigated the interruption of quorum sensing mediated by non-classical bioisosteres of the N-hexanoyl homoserine lactone with an azoline core. For this purpose, a set of selected 2-substituted azolines was synthesized, establishing the basis for a new protocol to synthesize 2-amino imidazolines. The synthesized compounds were evaluated as inhibitors of violacein production in Chromobacterium violaceum. Theoretical studies on bioisostere-protein interactions were performed using CviR. The results show that some azolines decreased violacein production, suggesting an antiquorum sensing profile against Gram-negative bacteria. Docking and molecular dynamic simulations together with binding free energy calculations revealed the exact binding and inhibitory profiles. These theoretical results show relationship with the in vitro activity of the azoline series.

RNA cleavage catalyzed by amphoteric bis(acyl)guanidinium derivatives

Described herein are two series (twelve compounds each) of very closely related guanidinium-based receptors and their ability to catalyze hydrolytic cleavage of a unique RNA substrate - oligo-dT flanked trans-Activation Responsive region of the HIV-1 mRNA, TAR RNA. The significant difference in activities of otherwise very similar compounds is discussed, and direct and indirect evidences supporting our interpretation are presented. The results indicate that improvements in catalytic efficiency could be achieved with little modification of the structure of a relatively weak catalyst, and that a crucial feature could be a finely calibrated interplay between anion-binding and proton-donating abilities. Copyright

Efficient synthesis of 2-arylamino-2-imidazolines and 2-aminobenzimidazoles with aminoiminomethanesulfonic acid derivatives

A highly efficient synthesis of 2-arylamino-2-imidazolines and 2-aminobenzimidazoles from aminoiminomethanesulfonic acid derivatives is described. The method is simple and practical, generating imidazoline and benzimidazoline derivatives in excellent isolated yields.

Novel heterocyclic derivatives bearing an amino radical, processes for their production and the pharmaceutical compositions containing them

This invention relates to novel heterocyclic derivatives bearing an amino group and to processes for making said compounds. More particularly this invention provides novel heterocyclic compounds the hetero ring of which has two hetero atoms, the same or different, substituted with a free or substituted amino group. These compounds are useful as active ingredients of drugs.

Synthesis of Guanidino-1,3,5-triazines Using DMF

2,4,6-Triguanidino-1,3,5-triazine and 2,4,6-tris(3-methylguanidino)-1,3,5-triazine were synthesized in 42 and 52percent yields, respectively, by the cyclotrimerization of cyanoguanidine and 1-methyl-3-cyanoguanidine using DMF as a solvent in the presence of hydrogen chloride. 1-Phenyl-3-cyanoguanidine, 1,2-dimethyl-3-cyanoguanidine, and 2-imidazolidinylidenecyanamide, however, were cyclodimerized to the corresponding guanidino-1,3,5-triazines in a similar manner.