Bioorganic and Medicinal Chemistry Letters p. 281 - 284 (1998)
Update date:2022-08-11
Topics:
Rosen, Terry J.
Coffman, Karen J.
McLean, Stafford
Crawford, Rosemary T.
Bryce, Dianne K.
Gohda, Yoshiko
Tsuchiya, Megumi
Nagahisa, Atsushi
Nakane, Masami
Lowe III, John A.
The synthesis and SAR of benzylamine side chain analogs of the NK-1 receptor antagonist CP-99,994 are described. The 5-trifluoromethoxy analog, CP-122,721, shows superior in vivo blockade of NK-1 receptor mediated responses.
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