A short and efficient synthesis of echiguanines A and B: Potent inhibitors of phosphatidylinositol-4-kinase

Article abstract of DOI:10.1016/S0040-4039(00)76939-5

An efficient synthesis which utilizes a palladium catalyzed carbonylation reaction between 2-pivaloyl-7-iodo-7-deazaguanine and 3-aminopropionitrile as a key step was developed for the preparation of a new class of pyrrolopyrimidine based PI 4-Kinase inhibitors: Echiguanines A and B.