Novel and expeditious microwave-assisted three-component reactions for the synthesis of spiroimidazolin-4-ones

DOI: 10.1021/jo060228q

Source and publish data:

Journal of Organic Chemistry p. 3137 - 3140 (2006)

Update date:2022-08-11

Topics:

Authors:

Ye, Ping

Sargent, Katie

Stewart, Ethan

Liu, Ji-Feng

Yohannes, Daniel

Yu, Libing

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Article abstract of DOI:10.1021/jo060228q

Highly efficient methods for the syntheses of spiroimidazolinones via microwave-assisted three-component one-pot sequential reactions or one-pot domino reactions are described. The efficiency and utility of the methods have been demonstrated by quickly accessing the antihypertensive drug irbesartan (2).

Full text of DOI:10.1021/jo060228q

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