DIASTEREOSELECTIVE REDUCTION OF AN α-KETO-ESTER DERIVED FROM (-)-8-PHENYLMENTHOL: A 4-step synthesis of R-Halostachine analogue

Article abstract of DOI:10.1016/S0957-4166(00)82014-5

An efficient (80percent total yield) 4-step synthesis of 94percent e.e.R-(-)-Halostachine analogue is described.The method offers the possibility to introduce various substituents onto the aromatic ring and various alkyl groups on the amine.A one-step and high yield (ca.100percent) conversion of esters into amides is presented.