Highly Diastereoselective Alkylations of Chiral Amide Enolates: New Routes to Hydroxyethylene Dipeptide Isostere Inhibitors of HIV-1 Protease

DOI: 10.1021/jo00036a004

Source and publish data:

Journal of Organic Chemistry p. 2771 - 2773 (1992)

Update date:2022-08-16

Topics:

Authors:

Askin, D.

Wallace, M. A.

Vacca, J. P.

Reamer, R. A.

Volante, R. P.

Shinkai, I.

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Article abstract of DOI:10.1021/jo00036a004

The nonchelate enforced chiral amide enolates derived from 4-7 react with alkyl iodide and protected α-amino epoxide electrophiles to produce the HIV protease inhibitors 10 and 16-19 with high diastereoselectivity.

Full text of DOI:10.1021/jo00036a004

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