Synthesis and cytotoxic activity of 6-vinyl- and 6-ethynyluridine and 8- vinyl- and 8-ethynyladenosine

Article abstract of DOI:10.1021/jm00001a025

It is well-known that the introduction of vinyl and ethynyl moieties into nucleosides is of crucial importance for cytostatic, antiviral, or other biological activities. In this study 6- and 8-vinyl- and -ethynyluridine and -adenosine were prepared by a g