Asymmetric synthesis of optically active 1,3-oxathiolane nucleoside analogues

DOI: 10.1080/07328319808004709

Source and publish data:

Nucleosides and Nucleotides p. 1739 - 1745 (1998)

Update date:2022-08-17

Topics:

Authors:

Caputo, Romualdo

Guaragna, Annalisa

Palumbo, Giovanni

Pedatella, Silvana

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Article abstract of DOI:10.1080/07328319808004709

A ready asymmetric synthesis of 3'-oxa-4'-thionucleosides has been accomplished in three main steps from benzoyloxyethanal. The synthesis is characterized by high overall yield and appreciable enantiomeric excesses. It represents a general synthetic scheme to prepare a wide range of heterosubstituted sulfur-containing nucleoside analogues.

Full text of DOI:10.1080/07328319808004709

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Product name:1,3-oxathiolan-2-ylmethyl benzoate

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