Selective Oxidation of Alcohols with a New Reagent
433
combined filtrates are evaporated to give crude product, which is purified by
preparative TLC with hexane–ethyl acetate (8:2) to afford 122 mg (85%) of
2
-butanone.
Oxidation of Cyclohexanol to Cyclohexanone
The Fe(NO ) -aluminum silicate reagent (2.2 g) is placed in a flask together
3
3
with CH Cl (15 mL), and the mixture is magnetically stirred. A solution of
2
2
cyclohexanol (100 mg, 1 mmol) in CH Cl (3 mL) is added, and after 3 h at
2
2
gentle reflux, the solid is filtered and washed with CH Cl (3 Â 5 mL). The
2
2
combined filtrates are evaporated to give crude product, which is purified
by preparative TLC with hexane–ethyl acetate (8:2) to afford 84 mg (86%)
of cyclohexanone.
Oxidation of Diphenylmethanol to Benzophenone
The Fe(NO ) -aluminum silicate reagent (2.2 g) is placed in a flask together
3
3
with CH Cl (15 mL), and the mixture is magnetically stirred. A solution of
2
2
diphenylmethanol (184 mg, 1 mmol) in CH Cl (3 mL) is added, and after
2
2
1
h at gentle reflux, the solid is filtered and washed with CH Cl2
2
(
3 Â 5 mL). The combined filtrates are evaporated to give crude product,
which is purified by preparative TLC with hexane–ethyl acetate (8:2) to
afford 178 mg (98%) of benzophenone.
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3
4
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