Studies on pyrrolidones. An improved synthesis of pyroglutamoyl chloride

Article abstract of DOI:10.1080/00397919408010572

The reaction of trimethylsilyl pyroglutamate with oxalyl chloride at room temperature easily yields pyroglutamoyl chloride. This unstable compound, obtained with difficulty by other methods, is suitable for the preparation of pyroglutamic esters and amides.

Full text of DOI:10.1080/00397919408010572

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Synthetic Communications: An
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Studies on Pyrrolidinones.
An Improved Synthesis of
Pyroglutamoyl Chloride
Benoit Rigo a , Samira El Ghammarti a , Philippe
Gautret a & Daniel Couturier b
a Laboratoire Chimie Organique et Environnement,
Ecole des Hautes Etudes Industrielles, 13 rue de
Toul, 59046, Lille Cédex, France
b Université des Sciences et Technologies de Lille,
59655, Villeneuve d'Ascq Cédex, France
Available online: 23 Sep 2006
To cite this article: Benoit Rigo, Samira El Ghammarti, Philippe Gautret &
Daniel Couturier (1994): Studies on Pyrrolidinones. An Improved Synthesis of
Pyroglutamoyl Chloride, Synthetic Communications: An International Journal for Rapid
Communication of Synthetic Organic Chemistry, 24:18, 2597-2607
To link to this article: http://dx.doi.org/10.1080/00397919408010572
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