Steroids p. 59 - 63 (1993)
Update date:2022-09-26
Topics:
Kirk, David N.
Schroeder, Martin H.
Latif, Syed A.
Souness, Graham W.
Morris, David J.
The 2α-hydroxy and 2β-hydroxy derivatives of aldosterone have been synthesized chemically from aldosterone, after the earlier identification of 2α-hydroxylated metabolites formed in liver.Both 2α- and 2β-hydroxyaldosterone are potent mineralocorticoids, with activities on the order of 1/10 that of aldosterone on the basis of a rat bioassay. Keywords: steroids; 2α-hydroxyaldosterone; 2β-hydroxyaldosterone; mineralocorticoid activity; liver metabolism
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Doi:10.1016/S0040-4039(00)84352-X
(1986)Doi:10.1016/0304-5102(93)85084-7
(1993)Doi:10.1002/aoc.4098
(2018)Doi:10.1021/ja01863a008
(1940)Doi:10.1039/c3ce42449a
(2014)Doi:10.1016/S0040-4039(00)60440-9
(1993)
