2-Bromo-2-nitropropane/Zn promoted reductive cyclizations of ortho-substituted nitroarenes toward 2,1-benzisoxazole derivatives

Article abstract of DOI:10.3987/com-96-7682

Under the mild conditions, reductive cyclizations of 2-nitrobenzaldehydes or 2′-nitroacetophenone towards 2,1-benzisoxazoles were accomplished in the presence of 2-bromo-2-nitropropane/Zn in methanolic solution. The synthetic utility and the role of 2-bromo-2-nitropropane were investigated.