Enantioselective Synthesis of β-Amino Acids. 6. High 1,2-Stereoinduction in the Preparation of Enantiopure 2(R)-Hydroxy-3(R)-N-benzoylamino-3-phenylpropionic Acid (Like Stereoisomer of Taxol's Side Chain).

Article abstract of DOI:10.1016/0040-4039(95)00859-B

The remarkably high 1,2-stereoinduction encountered in the hydroxylation of 1-benzoyl-3-methyl-6(S)-phenylperhydropyrimidin-4-one <(S)2> allows for the preparation of enantiopure N-benzoyl (2R,3R)-3-phenylisoserine, the like stereoisomer of taxol's C-13 side chain.