Synthesis of certain 6-(arylthio)uracils as potential antiviral agents

Article abstract of DOI:10.1080/10426500108040231

A series of 6-(Arylthio)uracils have been prepared via condensation of 6-chlorouracil or 5-ethyl-6-chlorouracil with the corresponding thiopnenol derivatives in pyridine or ethanolic potassium hydroxide. The synthesized compounds were tested for their antiviral activity. Some of the 5-ethyl-6-(arylthio)uracil derivatives 10a-g showed moderate activities against hepatitis B Virus (HBV) and HIV-1 virus.

Full text of DOI:10.1080/10426500108040231

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Phosphorus, Sulfur, and Silicon
and the Related Elements
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SYNTHESIS OF CERTAIN
6-(ARYLTHIO)URACILS AS
POTENTIAL ANTIVIRAL AGENTS
a
a
Ali A. El-emam , Magda N.A. Nasr , Erik B.
b
c
c
Pedersen , Tarek Fouad & Claus Nielsen
a
Department of Medicinal Chemistry, Faculty of
Pharmacy, University of Mansoura, Mansoura, 35516,
Egypt
b
Department of Chemistry, University of Southern
Denmark, 5230, Odense M, Denmark
c
Department of virology, State Serum Institute,
2300, Copenhagen, Denmark
Published online: 04 Oct 2006.
To cite this article: Ali A. El-emam , Magda N.A. Nasr , Erik B. Pedersen , Tarek Fouad
&
Claus Nielsen (2001): SYNTHESIS OF CERTAIN 6-(ARYLTHIO)URACILS AS POTENTIAL
ANTIVIRAL AGENTS, Phosphorus, Sulfur, and Silicon and the Related Elements, 174:1,
5-35
2
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