Highly Efficient Enzymatic Asymmetric Reduction by Use of Regenerating NADPH in Bakers' Yeast Cell-Free Extract

Article abstract of DOI:10.1016/S0040-4039(00)60730-X

Bakers' yeast cell-free extract was found to reduce 1-acetoxy-2-alkanones to (S)-1-acetoxy-2-alkanols in 59-88percent yield and 95 - >99percent ee by use of a catalytic amount of NADPH with glucose as a hydride source and without addition of any enzyme for the cofactor regeneration.