Practical, large-scale synthesis of 2,2-dimethyl-5-hydroxy-4-oxo-benzo- 1,4-dioxin

Article abstract of DOI:10.1080/00397919408020778

Modification of a known procedure employing the interaction of thionyl chloride, acetone, and 2,6-dihydroxybenzoic acid was found, to provide the title compound in multikilogram quantities of acceptable yield and purity.

Full text of DOI:10.1080/00397919408020778

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Synthetic Communications: An
International Journal for Rapid
Communication of Synthetic
Organic Chemistry
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Practical, Large-Scale Synthesis
of 2,2-Dimethyl-5-hydroxy-4-
oxo-benzo-1,4-dioxin
Anthony Hadfield a , Harold Schweitzer a , Michael P.
Trova b & Kenneth Green a
a Department of Chemical Process Development ,
American Cyanamid Co. , Pearl River, New York,
10965
b Department of Chemistry, Oncology and
Immunology, Medical Research Division , American
Cyanamid Co. , Pearl River, New York, 10965
Published online: 23 Sep 2006.
To cite this article: Anthony Hadfield , Harold Schweitzer , Michael P. Trova &
Kenneth Green (1994) Practical, Large-Scale Synthesis of 2,2-Dimethyl-5-hydroxy-4-
oxo-benzo-1,4-dioxin, Synthetic Communications: An International Journal for
Rapid Communication of Synthetic Organic Chemistry, 24:7, 1025-1028, DOI:
10.1080/00397919408020778
To link to this article: http://dx.doi.org/10.1080/00397919408020778
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