Straightforward synthesis of optically pure methyl (S)-2-phthalimido-4-oxobutanoate and some of its acetal and thioacetal derivatives

Article abstract of DOI:10.1055/s-1995-4056

An improved procedure for the synthesis of optically pure methyl (S)-2-phthalimido-4-oxobutanoate (3a) and some of its acetal and thioacetal derivatives 4, 5 and 7 from cheap commercially available L-methionine methyl ester hydrochloride (1a) is described.