Journal of Pharmaceutical Sciences p. 1015 - 1019 (1992)
Update date:2022-08-17
Topics:
Moos
Bergmeier
Coughenour
Davis
Hershenson
Kester
McKee
Marriott
Schwarz
Tecle
Thomas
Arecoline, arecaidine, and a series of derivatives, differing by the presence or absence of methyl groups at positions on the periphery of the molecule, were prepared, and their binding to muscarinic acetylcholine receptors was tested. On the basis of this study, muscarinic agonism for arecoline series is governed by strict structure-activity relationships, as previously observed for other agonist series. Only minor changes in nitrogen substitution were tolerated in the present series of arecoline derivatives.
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