3-Pyridinecarbonyl chloride, 4-methyl- (9CI)

Base Information

• Chemical Name: 3-Pyridinecarbonyl chloride, 4-methyl- (9CI)
• CAS No.: 155136-54-2
• Molecular Formula: C7H6 Cl N O
• Molecular Weight: 155.58164
• Hs Code.: 2933399090
• Mol file: 155136-54-2.mol

Synonyms:3-Pyridinecarbonyl chloride, 4-methyl- (9CI)

Chemical Property of 3-Pyridinecarbonyl chloride, 4-methyl- (9CI)

Chemical Property:

• PSA: 29.96000
• LogP: 1.76900

Purity/Quality:

99%, ^*data from raw suppliers

4-Methylnicotinoyl chloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Pyridinecarbonyl chloride, 4-methyl- (9CI)

There total 5 articles about 3-Pyridinecarbonyl chloride, 4-methyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methylnicotinic acid (3222-50-2) → 4-methylnicotinoyl chloride (155136-54-2)

Guidance literature:

With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; 1.) 0 deg C, 15 min; 2.) 30 deg C, 2 h;

DOI:10.1002/hlca.19940770118

Reference yield:

4-methylpyridine-3-carboxylic acid hydrochloride (94015-05-1) → 4-methylnicotinoyl chloride (155136-54-2)

Guidance literature:

With thionyl chloride; for 2h; Heating;

DOI:10.1002/jps.2600811012

Reference yield:

3-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)pyridine (68981-86-2) → 4-methylnicotinoyl chloride (155136-54-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 2.) S / 1.) THF, ether, a) -78 deg C, 1 h, b) RT, 1 h, 2.) toluene, reflux, 2 h

2: 72 percent / conc. aq. HCl / 18 h / Heating

3: SOCl₂ / 2 h / Heating

With hydrogenchloride; thionyl chloride;

DOI:10.1002/jps.2600811012

upstream raw materials:

4-methylnicotinic acid

4-methylpyridine-3-carboxylic acid hydrochloride

3-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)pyridine

3-(4',4'-dimethyl-4',5'-dihydro-oxazol-2'-yl)-4-methylpyridine

Downstream raw materials:

C₂₃H₃₀N₄O

N-(3-chlorophenyl)-N-((8-fluoro-2-oxo-1,2-dihydroquinolin-4-yl)methyl)-4-methylnicotinamide

N-(3-chlorophenyl)-N-((7,8-difluoro-2-oxo-1,2-dihydroquinolin-4-yl)methyl)-4-methylnicotinamide

methyl 3-(3-methoxyphenyl)-3-{(4-methylbenzyl)[(4-methyl-3-pyridinyl)carbonyl]amino}propanoate