Deracemization of (±)-2,2-disubstituted epoxides via enantioconvergent chemoenzymatic hydrolysis using nocardia EH1 epoxide hydrolase and sulfuric acid

DOI: 10.1016/S0040-4039(97)00201-3

Source and publish data:

Tetrahedron Letters p. 1753 - 1754 (1997)

Update date:2022-08-11

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Authors:

Orru, Romano V.A.

Kroutil, Wolfgang

Faber, Kurt

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Article abstract of DOI:10.1016/S0040-4039(97)00201-3

2-Substituted (S)-1,2-diols were prepared in a one-pot procedure with >90% ee and >90% isolated yield via deracemization of (±)-2,2-disubstituted oxiranes through sequential (i) biocatalytic asymmetric hydrolysis using Nocardia EH1 epoxide hydrolase and (

Full text of DOI:10.1016/S0040-4039(97)00201-3

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